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Kremezin

Formulation: 
Each 2gram Polyethylene-laminated aluminum sachet contains Spherical Carbon Adsorbent 2grams, Available in box of 84s, Black odorless granules

Pharmacology:
When this product was administered orally to patients with chronic renal failure in the conservative therapy , it inhibited the increase of serum creatinine , improved uremic symptoms & prolonged the time to the  initiation of dialysis.

Mechanism of Action:
When this product is administered orally to patients with chronic renal failure , it improves the uremic symptoms & prolongs the time to initiation of dialysis , since the uremic toxins are adsorbed by this product in the digestive tract & excreted with the feces.

Pharmacokinetics:
Absorption & excretion ( reference : Mice )
When C-labeled Spherical Carbon Adsorbent ( Kremezin ) was administered orally to mice , it was excreted with the feces almost completely within 24 hours after dministration & no in vivo absorption or accumulation of this product were noted.

Indications:
For improvement of uremic symptoms & for prolonging the time to initiation of dialysis in chronic renal failure ( progressive )

Dosage & Administration:
For oral use, the recommended dose is 1g per 10kg bw divided 3 times daily.

Storage Conditions:

Store at temperatures not exceeding 40 °centigrade . Protect from moisture.

Caution:
Food , Drug , Devices & Cosmetic Act prohibits dispensing without the physician’s prescription .

  • References :
  • Akizawa, T. et al. : Kidney & Dialysis , 45(3) , 373( 1998 )
  • Sugano, M. et al. : The Clinical Report , 21(5) , 2411(1987)
  • Koshikawa, S. et al. : Kidney & Dialsis , 23(2) , 373(1987)
  • Koide, K. et al. : Clinical Evaluation , 15(3) , 527(1987)
  • Koshikawa, S. et al. : Kidney & Dialsis , 21(1) , 199(1986)
  • Kanai, F. et al. :Japanese Journal of Nephrology , 28(9) , 1249(1986)
  • Sakai, T. et al. : Japanese Journal of Nephrology , 31(4) , 359(1989)
  • Koide, K. et al. : Japanese Journal of Clinical Medicine , 43(Special Issue) 
  • Newly-revised Maintenance Dialysis, 422(1985)